A Problem With the Correlation Coefficient as a Measure of Gene Expression Divergence
نویسندگان
چکیده
منابع مشابه
A problem with the correlation coefficient as a measure of gene expression divergence.
The correlation coefficient is commonly used as a measure of the divergence of gene expression profiles between different species. Here we point out a potential problem with this statistic: if measurement error is large relative to the differences in expression, the correlation coefficient will tend to show high divergence for genes that have relatively uniform levels of expression across tissu...
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Information regarding gene coexpression is useful to predict gene function. Several databases have been constructed for gene coexpression in model organisms based on a large amount of publicly available gene expression data measured by GeneChip platforms. In these databases, Pearson's correlation coefficients (PCCs) of gene expression patterns are widely used as a measure of gene coexpression. ...
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ژورنال
عنوان ژورنال: Genetics
سال: 2009
ISSN: 1943-2631
DOI: 10.1534/genetics.109.110247